Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.38 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.38 |
| ▸ | CACNB1 | Q02641 | 2/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.38 |
| ▸ | FAAH | O00519 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28548632 | 0.85 | NPC1 (0.41) | DPP8MAPK1RAB9AMEN1KMT2A | |
| SCHEMBL30910913 | 0.82 | CACNA1B (0.44) | DPP8CACNA1BCACNA2D1CACNB1CACNA1C | |
| SCHEMBL21831199 | 0.82 | CNR1 (0.43) | DPP8CACNA1BCACNA2D1CACNB1CACNA1C | |
| SCHEMBL21831876 | 0.80 | DPP8 (0.43) | DPP8CACNA1BCACNA2D1CACNB1CACNA1C | |
| SCHEMBL21910157 | 0.79 | OPRD1 (0.35) | DPP8SMN1; SMN2MGLLMAPT | |
| SCHEMBL21831121 | 0.79 | DPP8 (0.57) | DPP8CACNA1BCACNA2D1CACNB1CACNA1C | |
| SCHEMBL21831233 | 0.79 | DPP8 (0.57) | DPP8CACNA1BCACNA2D1CACNB1CACNA1C | |
| SCHEMBL21831122 | 0.79 | DPP8 (0.57) | DPP8CACNA1BCACNA2D1CACNB1CACNA1C | |
| SCHEMBL21831360 | 0.77 | DPP8 (0.43) | DPP8CACNA1BCACNA2D1CACNB1CACNA1C | |
| SCHEMBL21831289 | 0.77 | DPP8 (0.43) | DPP8CACNA1BCACNA2D1CACNB1CACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112654621-B | Substituted naphthyridinone compounds useful as T cell activators | 百时美施贵宝公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-112654621-A | Substituted naphthyridinone compounds useful as T cell activators | 百时美施贵宝公司 | 2021-04-13 | — | — | CN | disclosed |