Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 13/20 | 0.57 |
| ▸ | CHRNA4 | P43681 | 13/20 | 0.57 |
| ▸ | CDK4 | P11802 | 5/20 | 0.47 |
| ▸ | CCND1 | P24385 | 4/20 | 0.47 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CCND3 | P30281 | 1/20 | 0.43 |
| ▸ | CDK7 | P50613 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | CCNH | P51946 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4246373 | 0.95 | CHRNB2 (0.53) | CHRNB2CHRNA4CDK4CCND1CDK6 | |
| Hydrochloric Acid SCHEMBL4244130 | 0.93 | CHRNB2 (0.51) | CHRNB2CHRNA4CDK4CCND1CDK6 | |
| Trifluoroacetic Acid SCHEMBL18453329 | 0.90 | CHRNB2 (0.47) | CHRNB2CHRNA4CDK4CCND1CDK6 | |
| SCHEMBL18453953 | 0.86 | MAPT (0.44) | CHRNB2CHRNA4CDK4CCND1CDK6 | |
| Trifluoroacetic Acid SCHEMBL28705254 | 0.84 | AOC3 (0.44) | CHRNB2CHRNA4CDK4CCND1CDK6 | |
| Trifluoroacetic Acid SCHEMBL29544383 | 0.84 | AOC3 (0.44) | CHRNB2CHRNA4CDK4CCND1CDK6 | |
| Trifluoroacetic Acid SCHEMBL18453319 | 0.84 | AOC3 (0.44) | CHRNB2CHRNA4CDK4CCND1CDK6 | |
| SCHEMBL24483273 | 0.80 | CHRNB2 (0.49) | CHRNB2CHRNA4CDK4CCND1CDK6 | |
| SCHEMBL29544286 | 0.78 | POLB (0.47) | CDK4CCND1CDK6CCNA2CDK2 | |
| SCHEMBL29389581 | 0.78 | FLT3 (0.47) | CDK4CCND1CDK6CCNT1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113336746-A | N- (pyridin-2-yl) -4- (thiazol-5-yl) pyrimidin-2-amines as therapeutic compounds | 常州千红生化制药股份有限公司 | 2021-09-03 | — | — | CN | disclosed |
| CN-108349964-B | N- (pyridin-2-yl) -4- (thiazol-5-yl) pyrimidin-2-amines as therapeutic compounds | 常州千红生化制药股份有限公司 | 2021-06-01 | — | — | CN | disclosed |