Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 12/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 2/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2856340 | 1.00 | NOTUM (0.43) | NOTUMFFAR1FFAR4SERPINE1MGLL | |
| SCHEMBL2856341 | 1.00 | NOTUM (0.43) | NOTUMFFAR1FFAR4SERPINE1MGLL | |
| SCHEMBL4515377 | 0.88 | ENPP2 (0.42) | FFAR1ENPP2 | |
| SCHEMBL2853997 | 0.85 | PSEN1 (0.51) | FFAR1FFAR4 | |
| SCHEMBL8267623 | 0.85 | PSEN1 (0.51) | FFAR1FFAR4 | |
| SCHEMBL2853999 | 0.85 | PSEN1 (0.51) | FFAR1FFAR4 | |
| SCHEMBL13604399 | 0.85 | FFAR1 (0.43) | FFAR1FFAR4 | |
| SCHEMBL2876179 | 0.85 | FFAR1 (0.43) | FFAR1FFAR4 | |
| SCHEMBL2877745 | 0.85 | FFAR1 (0.43) | FFAR1FFAR4 | |
| SCHEMBL2863855 | 0.81 | FFAR1 (0.38) | FFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805141-B1 | PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME (GB) | 2010-01-20 | — | — | EP | disclosed |