Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.31 |
| ▸ | HPGD | P15428 | 3/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28523051 | 0.82 | PTPN1 (0.31) | CYP2D6CYP2C19 | |
| SCHEMBL20564353 | 0.82 | HPGD (0.41) | KDM4EKMT2ASMN1; SMN2LMNANPC1 | |
| SCHEMBL27378232 | 0.79 | KLK1 (0.33) | — | |
| SCHEMBL5853857 | 0.79 | KLK1 (0.33) | — | |
| SCHEMBL7774207 | 0.78 | HPGD (0.37) | KMT2ASMN1; SMN2LMNARAB9AMEN1 | |
| SCHEMBL158136 | 0.75 | — | — | |
| SCHEMBL1143957 | 0.73 | SMN1; SMN2 (0.38) | KDM4EKMT2ASMN1; SMN2LMNANPC1 | |
| SCHEMBL28403962 | 0.70 | HPGD (0.42) | KMT2ASMN1; SMN2LMNAMEN1ALDH1A1 | |
| SCHEMBL7953637 | 0.70 | MAPK1 (0.40) | KDM4ESMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL13722453 | 0.70 | SQOR (0.32) | SMN1; SMN2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110066278-B | Fused tricyclic compound and application thereof in medicines | 广东东阳光药业有限公司 | 2021-06-08 | — | — | CN | disclosed |