Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 5/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.43 |
| ▸ | PRKCA | P17252 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 2/20 | 0.32 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL292279 | 0.76 | PRKCQ (0.68) | PRKCQJAK2ROCK2PRKCDROCK1 | |
| SCHEMBL285150 | 0.66 | MAPK1 (0.40) | PRKCQJAK2ROCK2PRKCDROCK1 | |
| SCHEMBL2675526 | 0.64 | PRKCQ (0.67) | PRKCQJAK2ROCK2PRKCDROCK1 | |
| SCHEMBL3798633 | 0.64 | PRKCQ (0.59) | PRKCQJAK2ROCK2PRKCDROCK1 | |
| SCHEMBL285566 | 0.64 | CCNE2 (0.42) | CCNE2CCNE1CDK2 | |
| SCHEMBL285643 | 0.63 | JAK2 (0.37) | PRKCQJAK2ROCK2PRKCDROCK1 | |
| SCHEMBL9937393 | 0.63 | PRKCQ (0.43) | PRKCQJAK2ROCK2PRKCDROCK1 | |
| SCHEMBL10310900 | 0.63 | PRKCQ (0.53) | PRKCQJAK2ROCK2PRKCDROCK1 | |
| SCHEMBL13075228 | 0.61 | PRKCQ (0.51) | PRKCQJAK2ROCK2PRKCDROCK1 | |
| SCHEMBL2675149 | 0.60 | PRKCQ (1.00) | PRKCQJAK2ROCK2PRKCDROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427464-A1 | PYRAZOLOPYRIDINES | Vertex Pharmaceuticals Incorporated (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010129668-A1 | PYRAZOLOPYRIDINES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-11-11 | — | — | WO | disclosed |