Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 6/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | DNM1 | Q05193 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11099177 | 0.98 | TSHR (0.59) | TSHRHPGDALDH1A1CYP3A4DNM1 | |
| SCHEMBL29107035 | 0.95 | TSHR (0.59) | TSHRHPGDALDH1A1CYP3A4DNM1 | |
| SCHEMBL24901370 | 0.94 | TSHR (0.65) | TSHRHPGDALDH1A1CYP3A4TP53 | |
| SCHEMBL15253856 | 0.94 | TSHR (0.65) | TSHRHPGDALDH1A1CYP3A4TP53 | |
| SCHEMBL24901038 | 0.94 | TSHR (0.65) | TSHRHPGDALDH1A1CYP3A4TP53 | |
| SCHEMBL10583872 | 0.94 | TSHR (0.65) | TSHRHPGDALDH1A1CYP3A4TP53 | |
| SCHEMBL25143592 | 0.92 | TSHR (0.62) | TSHRHPGDALDH1A1CYP3A4TP53 | |
| SCHEMBL24900994 | 0.92 | TSHR (0.62) | TSHRHPGDALDH1A1CYP3A4TP53 | |
| SCHEMBL29106990 | 0.92 | TSHR (0.62) | TSHRHPGDALDH1A1CYP3A4TP53 | |
| SCHEMBL25143667 | 0.92 | TSHR (0.62) | TSHRHPGDALDH1A1CYP3A4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112898477-A | Preparation method and application of nano-silica modified soap-free fluorine-free cationic polyacrylate waterproof agent | 浙江工业职业技术学院 | 2021-06-04 | — | — | CN | disclosed |