Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 5/20 | 0.38 |
| ▸ | SMARCA4 | P51532 | 5/20 | 0.38 |
| ▸ | PBRM1 | Q86U86 | 5/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 6/20 | 0.37 |
| ▸ | CDK9 | P50750 | 6/20 | 0.37 |
| ▸ | GRM1 | Q13255 | 5/20 | 0.36 |
| ▸ | GRM5 | P41594 | 4/20 | 0.36 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19991661 | 0.86 | PBRM1 (0.53) | SMARCA2SMARCA4PBRM1NR1I2BRD4 | |
| SCHEMBL31179788 | 0.86 | GRM1 (0.54) | SMARCA2SMARCA4PBRM1GRM1GRM5 | |
| SCHEMBL23037443 | 0.86 | GRM1 (0.54) | SMARCA2SMARCA4PBRM1GRM1GRM5 | |
| SCHEMBL31179792 | 0.86 | GRM1 (0.54) | SMARCA2SMARCA4PBRM1GRM1GRM5 | |
| SCHEMBL5371432 | 0.78 | CCNT1 (0.47) | CCNT1CDK9GRM1GRM5ALDH1A1 | |
| SCHEMBL29029578 | 0.77 | ALDH1A1 (0.41) | ALDH1A1HPGDNPC1MAPTALOX15 | |
| SCHEMBL18081225 | 0.76 | SMARCA2 (0.54) | SMARCA2SMARCA4PBRM1NR1I2BRD4 | |
| SCHEMBL5376595 | 0.75 | ALDH1A1 (0.48) | SCDSCD5ALDH1A1HPGDNPC1 | |
| SCHEMBL28565843 | 0.75 | CNR1 (0.37) | SCDSCD5ALDH1A1NPC1MAPT | |
| SCHEMBL28428615 | 0.74 | MAPT (0.42) | CCNT1CDK9SCDSCD5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112771038-A | Pyridazine derivatives as SMARCA2/4 degradants | 奥里吉恩发现科技有限公司 | 2021-05-07 | — | — | CN | disclosed |