Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 10/20 | 0.55 |
| ▸ | FPR3 | P25089 | 3/20 | 0.48 |
| ▸ | FPR2 | P25090 | 3/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | KRAS | P01116 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28566888 | 1.00 | USP30 (0.55) | USP30FPR3FPR2SCN9AALDH1A1 | |
| SCHEMBL20045986 | 0.92 | USP30 (0.48) | USP30FPR3FPR2SCN9AKRAS | |
| SCHEMBL17803256 | 0.85 | USP30 (0.48) | USP30FPR3FPR2ALDH1A1KRAS | |
| SCHEMBL18928181 | 0.85 | USP30 (0.53) | USP30SCN9AALDH1A1PARP1NPC1 | |
| SCHEMBL28563886 | 0.85 | USP30 (0.53) | USP30SCN9AALDH1A1PARP1NPC1 | |
| SCHEMBL28572066 | 0.84 | USP30 (0.50) | USP30FPR3FPR2SCN9AALDH1A1 | |
| SCHEMBL28572069 | 0.84 | USP30 (0.50) | USP30FPR3FPR2SCN9AALDH1A1 | |
| SCHEMBL21874641 | 0.84 | GRM2 (0.40) | USP30HTT | |
| SCHEMBL21874640 | 0.84 | GRM2 (0.40) | USP30HTT | |
| SCHEMBL14247337 | 0.80 | USP30 (0.56) | USP30FPR3FPR2ALDH1A1KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108290861-B | 1-cyano-pyrrolidine derivatives as USP30 inhibitors | 特殊治疗有限公司 | 2021-05-25 | — | — | CN | disclosed |