Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.48 |
| ▸ | FPR2 | P25090 | 4/20 | 0.45 |
| ▸ | FPR3 | P25089 | 3/20 | 0.45 |
| ▸ | KRAS | P01116 | 4/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 2/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.38 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28566889 | 0.92 | USP30 (0.55) | USP30FPR2FPR3KRASHDAC1 | |
| SCHEMBL28566888 | 0.92 | USP30 (0.55) | USP30FPR2FPR3KRASHDAC1 | |
| SCHEMBL22716791 | 0.84 | NAMPT (0.46) | USP30HDAC1HDAC2NAMPTRORC | |
| SCHEMBL28327682 | 0.82 | AAK1 (0.36) | USP30KRASAAK1 | |
| SCHEMBL20444527 | 0.81 | AAK1 (0.49) | USP30FPR2FPR3KRASAAK1 | |
| SCHEMBL17803256 | 0.81 | USP30 (0.48) | USP30FPR2FPR3KRAS | |
| SCHEMBL15342503 | 0.78 | HDAC1 (0.49) | USP30FPR2FPR3KRASAAK1 | |
| SCHEMBL12801074 | 0.76 | USP30 (0.44) | USP30FPR2FPR3AAK1HDAC1 | |
| SCHEMBL21874640 | 0.76 | GRM2 (0.40) | USP30AAK1 | |
| SCHEMBL21874641 | 0.76 | GRM2 (0.40) | USP30AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018068017-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF RAS AND METHODS OF USE THEREOF | ARAXES PHARMA LLC (US) | 2018-04-12 | — | — | WO | disclosed |