Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.33 |
| ▸ | FAAH | O00519 | 3/20 | 0.32 |
| ▸ | NAAA | Q02083 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | ACR | P10323 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL28432879 | 0.87 | TDP1 (0.39) | NPC1TDP1PDCD1CD274FAAH | |
| Ethylene Glycol SCHEMBL27650882 | 0.83 | KDM4E (0.36) | PDCD1CD274FAAHNAAAKDM4E | |
| SCHEMBL14067104 | 0.81 | ITGB2 (0.38) | NPC1FAAHNAAAKDM4EALDH1A1 | |
| SCHEMBL102784 | 0.81 | ITGB2 (0.38) | NPC1FAAHNAAAKDM4EALDH1A1 | |
| Propylene Glycol SCHEMBL28554703 | 0.81 | TDP1 (0.36) | TDP1FAAHNAAAPTGS2CYP2C19 | |
| Hydrogen Sulfide SCHEMBL28295724 | 0.79 | ITGB2 (0.36) | NPC1FAAHNAAAKDM4EALDH1A1 | |
| Lithium SCHEMBL30114456 | 0.79 | ITGB2 (0.36) | NPC1FAAHNAAAKDM4EALDH1A1 | |
| Potassium SCHEMBL30808411 | 0.79 | ITGB2 (0.36) | NPC1FAAHNAAAKDM4EALDH1A1 | |
| SCHEMBL2232672 | 0.77 | KMT2A (0.36) | FAAHNAAAKDM4EALDH1A1LMNA | |
| SCHEMBL18695010 | 0.75 | LMNA (0.44) | KDM4EALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109762503-B | TPU bonding layer for heat-sealing adhesive tape, three-layer heat-sealing adhesive tape comprising TPU bonding layer, and preparation method and application of three-layer heat-sealing adhesive tape | 广东盈通新材料有限公司 | 2021-05-14 | — | — | CN | claimed |