SCHEMBL28567002

SCHEMBL28567002

Cc1c([SH]2C=CC=C2)n(COCCO)c(=O)[nH]c1=O

nearest known ligand 0.40

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
UPP1 Q16831 1/20 0.40
PNP P00491 3/20 0.36
ALDH1A1 P00352 1/20 0.36
HTT P42858 1/20 0.35
USP2 O75604 1/20 0.33
TSHR P16473 1/20 0.33
EDNRA P25101 1/20 0.33
HTR2A P28223 1/20 0.33
RECQL P46063 1/20 0.33
BLM P54132 1/20 0.33
HBB P68871 1/20 0.33
HSD17B10 Q99714 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9353761 0.72 UPP1 (0.40) UPP1PNPALDH1A1HTTUSP2
SCHEMBL9357433 0.72 UPP1 (0.40) UPP1PNPALDH1A1HTT
SCHEMBL9598080 0.72 UPP1 (0.48) UPP1PNPALDH1A1
SCHEMBL9353685 0.71 UPP1 (0.39) UPP1PNPALDH1A1HTTUSP2
SCHEMBL9357492 0.71 UPP1 (0.39) UPP1PNPALDH1A1HTTUSP2
SCHEMBL9357489 0.71 UPP1 (0.39) UPP1PNPALDH1A1HTTUSP2
SCHEMBL7219933 0.71 UPP1 (0.59) UPP1PNPALDH1A1
Hept SCHEMBL384288 0.69 UPP1 (0.48) UPP1PNPALDH1A1TSHR
SCHEMBL9357419 0.68 UPP1 (0.47) UPP1PNPALDH1A1
SCHEMBL9357481 0.68 UPP1 (0.47) UPP1ALDH1A1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112898544-A Difunctional conjugated microporous polymer containing pyrimidine ring and cyano and preparation method thereof 台州学院 2021-06-04 CN disclosed