SCHEMBL28569052

SCHEMBL28569052

COc1cccc2c1C(=O)C(=O)c1ccccc1-2

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 8/20 0.68
MEN1 O00255 6/20 0.68
KMT2A Q03164 6/20 0.68
ALDH1A1 P00352 5/20 0.68
KDM4E B2RXH2 4/20 0.68
TDP1 Q9NUW8 2/20 0.68
USP2 O75604 1/20 0.68
DUSP3 P51452 1/20 0.68
PTPRC P08575 2/20 0.59
PTPN1 P18031 1/20 0.59
EGFR P00533 1/20 0.59
PIM1 P11309 1/20 0.59
RAB9A P51151 6/20 0.58
SMN1; SMN2 Q16637 5/20 0.58
TOP1 P11387 1/20 0.56
POLB P06746 4/20 0.56
MAPK1 P28482 3/20 0.56
THRB P10828 2/20 0.56
PPARG P37231 2/20 0.56
NPSR1 Q6W5P4 2/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28573446 0.98 MAPT (0.66) MAPTMEN1KMT2AALDH1A1KDM4E
SCHEMBL29595070 0.98 MAPT (0.66) MAPTMEN1KMT2AALDH1A1KDM4E
SCHEMBL9264626 0.96 MAPT (0.74) MAPTMEN1KMT2AALDH1A1KDM4E
SCHEMBL612831 0.88 MAPT (0.74) MAPTMEN1KMT2AALDH1A1KDM4E
SCHEMBL29126288 0.86 MAPT (0.66) MAPTMEN1KMT2AALDH1A1KDM4E
SCHEMBL31435387 0.86 MAPT (0.70) MAPTMEN1KMT2AALDH1A1KDM4E
SCHEMBL3417492 0.85 EGFR (0.76) MAPTMEN1KMT2AALDH1A1KDM4E
SCHEMBL28575370 0.85 MEN1 (0.72) MAPTMEN1KMT2AALDH1A1KDM4E
SCHEMBL16174455 0.85 CA1 (0.57) MAPTMEN1KMT2AALDH1A1KDM4E
SCHEMBL5576493 0.85 CA1 (0.57) MAPTMEN1KMT2AALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112961176-B Preparation method of boron-dioxygen ring neutral radical compound 南京大学 2022-05-17 CN disclosed
CN-112961176-A Preparation method of boron-dioxygen ring neutral radical compound 南京大学 2021-06-15 CN disclosed