Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 3/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | USP7 | Q93009 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.37 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.37 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.37 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.37 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL522712 | 0.84 | MAP4K4 (0.30) | DYRK1ADYRK1B | |
| SCHEMBL28569265 | 0.80 | ESR2 (0.36) | ESR2MEN1NPC1RAB9AKMT2A | |
| SCHEMBL417021 | 0.76 | CCR1 (0.40) | — | |
| SCHEMBL413086 | 0.75 | ENPP3 (0.39) | — | |
| SCHEMBL4478005 | 0.75 | IRAK4 (0.34) | — | |
| SCHEMBL29533363 | 0.72 | HTR2C (0.35) | NPC1RAB9AABL1EGFRHCK | |
| SCHEMBL12147023 | 0.72 | PARP1 (0.34) | — | |
| SCHEMBL30643452 | 0.71 | KCNH2 (0.35) | MEN1RAB9AKMT2A | |
| SCHEMBL28667672 | 0.71 | — | — | |
| SCHEMBL23245974 | 0.69 | ENPP3 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112661751-B | Heterocyclic compounds as BCL-2 inhibitors | 南京天印健华医药科技有限公司 | 2024-06-14 | — | — | CN | disclosed |
| CN-112661751-A | Heterocyclic compounds as BCL-2 inhibitors | 南京天印健华医药科技有限公司 | 2021-04-16 | — | — | CN | disclosed |