Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Glycerin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.30 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycerin SCHEMBL1712541 | 0.94 | TP53 (0.58) | TP53LMNAALDH1A1THRBMEN1 | |
| Glycerin SCHEMBL27263776 | 0.94 | TP53 (0.58) | TP53LMNAALDH1A1THRBMEN1 | |
| Glycerin SCHEMBL28307053 | 0.94 | TP53 (0.58) | TP53LMNAALDH1A1THRBMEN1 | |
| Glycerin SCHEMBL1712543 | 0.94 | TP53 (0.58) | TP53LMNAALDH1A1THRBMEN1 | |
| Glycerin SCHEMBL29119760 | 0.94 | TP53 (0.58) | TP53LMNAALDH1A1THRBMEN1 | |
| Glycerin SCHEMBL3358540 | 0.94 | TP53 (0.58) | TP53LMNAALDH1A1THRBMEN1 | |
| Glycerin SCHEMBL11173648 | 0.94 | TP53 (0.58) | TP53LMNAALDH1A1THRBMEN1 | |
| Glycerin SCHEMBL29119754 | 0.94 | TP53 (0.58) | TP53LMNAALDH1A1THRBMEN1 | |
| Glycerin SCHEMBL27823536 | 0.91 | TP53 (0.55) | TP53LMNAALDH1A1THRBMEN1 | |
| Glycerin SCHEMBL28447412 | 0.88 | TP53 (0.52) | TP53LMNAALDH1A1THRBOR51E2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2599547-B1 | Method of synthesizing zirconium phosphate particles | RENAL SOLUTIONS INC (US) | 2019-03-27 | — | — | EP | disclosed |
| EP-2599547-A1 | Method of synthesizing zirconium phosphate particles | Renal Solutions, Inc. (US) | 2013-06-05 | — | — | EP | disclosed |
| US-7906093-B2 | Method of synthesizing zirconium phosphate particles | RENAL SOLUTIONS, INC. (US) | 2011-03-15 | — | — | US | disclosed |
| US-20100213412-A1 | Method Of Synthesizing Zirconium Phosphate Particles | RENAL SOLUTIONS, INC. (US) | 2010-08-26 | — | — | US | disclosed |
| US-7736507-B2 | Method of synthesizing zirconium phosphate particles | RENAL SOLUTIONS, INC. (US) | 2010-06-15 | — | — | US | disclosed |
| US-20090208399-A1 | Method Of Synthesizing Zirconium Phosphate Particles | RENAL SOLUTIONS, INC. (US) | 2009-08-20 | — | — | US | disclosed |
| US-7566432-B2 | Method of synthesizing zirconium phosphate particles | RENAL SOLUTIONS, INC. (US) | 2009-07-28 | — | — | US | disclosed |
| EP-1830960-A1 | METHOD OF SYNTHESIZING ZIRCONIUM PHOSPHATE PARTICLES | Renal Solutions, Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006071532-A1 | METHOD OF SYNTHESIZING ZIRCONIUM PHOSPHATE PARTICLES | RENAL SOLUTIONS, INC. (US) | 2006-07-06 | — | — | WO | disclosed |
| US-20060140840-A1 | Method of synthesizing zirconium phosphate particles | RENAL SOLUTIONS, INC. | 2006-06-29 | — | — | US | disclosed |