Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | STAT3 | P40763 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | PPIA | P62937 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | CDK9 | P50750 | 2/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28572006 | 1.00 | LMNA (0.41) | LMNASTAT3HTTSMN1; SMN2POLB | |
| SCHEMBL20067904 | 1.00 | LMNA (0.41) | LMNASTAT3HTTSMN1; SMN2POLB | |
| SCHEMBL23383007 | 0.80 | LMNA (0.37) | LMNAMAPTL3MBTL1LRRK2KDM4E | |
| SCHEMBL21514010 | 0.80 | LMNA (0.37) | LMNAMAPTL3MBTL1LRRK2KDM4E | |
| SCHEMBL20067907 | 0.79 | HTT (0.49) | LMNASTAT3HTTSMN1; SMN2POLB | |
| SCHEMBL28563970 | 0.79 | HTT (0.49) | LMNASTAT3HTTSMN1; SMN2POLB | |
| SCHEMBL31167021 | 0.78 | PDGFRB (0.41) | STAT3HTTSMN1; SMN2MAPTPDGFRB | |
| SCHEMBL20061330 | 0.78 | BACE1 (0.34) | — | |
| SCHEMBL17040912 | 0.75 | KDM1A (0.41) | LMNAHTTSMN1; SMN2MAPTPPIA | |
| SCHEMBL18862530 | 0.75 | KDM1A (0.41) | LMNAHTTSMN1; SMN2MAPTPPIA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107690433-B | Heteroaryl derivative or pharmaceutically acceptable salt thereof, preparation method thereof, and pharmaceutical composition for preventing or treating PI3 kinase-associated diseases comprising the same as active ingredient | 韩国化学研究院 | 2021-04-09 | — | — | CN | disclosed |