Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | BLM | P54132 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.51 |
| ▸ | DPP4 | P27487 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.51 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.51 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.51 |
| ▸ | GAPDH | P04406 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28563610 | 0.86 | SLC29A1 (0.52) | SMN1; SMN2ALDH1A1ADORA1ADORA3ADORA2A | |
| SCHEMBL29323480 | 0.83 | KDM4E (0.62) | SMN1; SMN2ALDH1A1KDM4EHTTBLM | |
| SCHEMBL29323111 | 0.83 | KDM4E (0.62) | SMN1; SMN2ALDH1A1KDM4EHTTBLM | |
| SCHEMBL28519188 | 0.83 | ADORA2A (0.46) | MAPTADORA1ADORA3ADORA2AADORA2B | |
| SCHEMBL28586588 | 0.80 | PIM1 (0.52) | SMN1; SMN2HTTTP53LMNADNMT1 | |
| SCHEMBL5556122 | 0.79 | SLC29A1 (0.58) | BLMTP53ADORA3SLC29A1SLC28A3 | |
| SCHEMBL29444502 | 0.78 | SLC29A1 (0.61) | SMN1; SMN2ALDH1A1HTTTSHRTP53 | |
| SCHEMBL1319619 | 0.78 | ADORA3 (0.56) | SMN1; SMN2ALDH1A1KDM4EHTTBLM | |
| SCHEMBL8371824 | 0.78 | ADORA3 (0.56) | SMN1; SMN2ALDH1A1KDM4EHTTBLM | |
| SCHEMBL31265252 | 0.78 | ADORA3 (0.56) | SMN1; SMN2ALDH1A1KDM4EHTTBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112812145-B | Benzimidazole derivative BI293 and preparation method and application thereof | 中国人民解放军东部战区总医院 | 2021-12-21 | — | — | CN | claimed |
| CN-112812145-A | Benzimidazole derivative BI293 and preparation method and application thereof | 中国人民解放军东部战区总医院 | 2021-05-18 | — | — | CN | claimed |
| CN-112812145-B | Benzimidazole derivative BI293 and preparation method and application thereof | 中国人民解放军东部战区总医院 | 2021-12-21 | — | — | CN | disclosed |
| CN-112812145-A | Benzimidazole derivative BI293 and preparation method and application thereof | 中国人民解放军东部战区总医院 | 2021-05-18 | — | — | CN | disclosed |