SCHEMBL28573448

SCHEMBL28573448

CC/C(=C\Cc1cccc2ccccc12)C(N)=O

nearest known ligand 0.46

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 2/20 0.46
TDP1 Q9NUW8 1/20 0.45
HPGD P15428 1/20 0.44
HTT P42858 1/20 0.44
L3MBTL1 Q9Y468 2/20 0.42
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
PARP10 Q53GL7 1/20 0.42
ACP3 P15309 1/20 0.41
CYP1A2 P05177 2/20 0.40
LMNA P02545 1/20 0.40
PKM P14618 1/20 0.40
ATM Q13315 1/20 0.40
CTNNB1 P35222 1/20 0.39
CYP2D6 P10635 1/20 0.39
CYP2C19 P33261 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8600665 0.82 MTNR1A (0.48) MTNR1ATDP1HPGDHTTL3MBTL1
SCHEMBL11792152 0.76 TDP1 (0.53) MTNR1ATDP1HPGDHTTMEN1
SCHEMBL3682565 0.74 XPO1 (0.51) MTNR1ATDP1HPGDHTTACP3
SCHEMBL17595169 0.74 TDP1 (0.53) MTNR1ATDP1MEN1KMT2AACP3
SCHEMBL28563405 0.73 CYP1A2 (0.46) CYP1A2
SCHEMBL24061867 0.72 HPGD (0.43) MTNR1ATDP1HPGDHTTL3MBTL1
SCHEMBL24914145 0.72 HPGD (0.49) MTNR1ATDP1HPGDHTTL3MBTL1
SCHEMBL7443128 0.72 MTNR1A (0.50) MTNR1ATDP1HPGDHTTL3MBTL1
SCHEMBL5609945 0.71 TDP1 (0.53) MTNR1ATDP1HPGDHTTL3MBTL1
SCHEMBL10389881 0.71 TDP1 (0.53) MTNR1ATDP1L3MBTL1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109232284-B Polysubstituted enamine aldehyde derivative and preparation method thereof 华侨大学 2021-05-11 CN disclosed