Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 20/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL108484 | 0.97 | GABRA5 (0.63) | GABRA5 | |
| SCHEMBL285702 | 0.93 | GABRA5 (0.66) | GABRA5 | |
| SCHEMBL103674 | 0.86 | GABRA5 (0.60) | GABRA5 | |
| SCHEMBL535818 | 0.84 | GABRA5 (0.51) | GABRA5 | |
| SCHEMBL285894 | 0.84 | GABRA5 (0.62) | GABRA5 | |
| SCHEMBL285878 | 0.84 | GABRA5 (0.67) | GABRA5 | |
| SCHEMBL107842 | 0.83 | GABRA5 (0.52) | GABRA5 | |
| SCHEMBL285941 | 0.82 | GABRA5 (0.66) | GABRA5 | |
| SCHEMBL109555 | 0.81 | GABRA5 (0.47) | GABRA5 | |
| SCHEMBL285864 | 0.81 | GABRA5 (0.67) | GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427457-A1 | ISOXAZOLE-PYRIDINE DERIVATIVES AS GABA MODULATORS | F. Hoffmann-La Roche AG (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010127978-A1 | ISOXAZOLE-PYRIDINE DERIVATIVES AS GABA MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-11-11 | — | — | WO | disclosed |