Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 10/20 | 0.56 |
| ▸ | EGFR | P00533 | 8/20 | 0.56 |
| ▸ | INSR | P06213 | 1/20 | 0.54 |
| ▸ | IGF1R | P08069 | 1/20 | 0.54 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.54 |
| ▸ | CDK7 | P50613 | 1/20 | 0.50 |
| ▸ | CDK9 | P50750 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28574065 | 0.91 | PTK2 (0.55) | PTK2EGFRINSRIGF1RALK | |
| SCHEMBL28914473 | 0.89 | EGFR (0.55) | PTK2EGFRINSRIGF1RALK | |
| SCHEMBL28569393 | 0.88 | INSR (0.58) | PTK2EGFRINSRIGF1RALK | |
| SCHEMBL28914390 | 0.87 | EGFR (0.56) | PTK2EGFRINSRIGF1RALK | |
| SCHEMBL28564170 | 0.85 | EGFR (0.57) | PTK2EGFRINSRIGF1RALK | |
| SCHEMBL28574074 | 0.85 | PTK2 (0.72) | PTK2EGFRINSRIGF1RALK | |
| SCHEMBL28577098 | 0.83 | PTK2 (0.46) | PTK2EGFRALKCDK7CDK9 | |
| SCHEMBL28566195 | 0.81 | EGFR (0.57) | PTK2EGFRINSRIGF1RALK | |
| SCHEMBL28571162 | 0.80 | EGFR (0.68) | PTK2EGFRINSRIGF1RALK | |
| SCHEMBL28562993 | 0.80 | PTK2 (0.62) | PTK2EGFRINSRIGF1RALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112771032-A | Pyrimidine pyrazole compounds as fourth generation EGFR inhibitors | 江苏先声药业有限公司 | 2021-05-07 | — | — | CN | disclosed |