Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 3/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 8/20 | 0.33 |
| ▸ | PDE1A | P54750 | 1/20 | 0.31 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.31 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.31 |
| ▸ | PDE9A | O76083 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29921383 | 1.00 | CYP4F2 (0.43) | CYP4F2CYP4A11LMNAALDH1A1POLB | |
| SCHEMBL29147608 | 0.85 | CYP4F2 (0.42) | CYP4F2CYP4A11LMNAALDH1A1POLB | |
| SCHEMBL30633933 | 0.85 | CYP4F2 (0.42) | CYP4F2CYP4A11LMNAALDH1A1POLB | |
| SCHEMBL29147605 | 0.85 | CYP4F2 (0.42) | CYP4F2CYP4A11LMNAALDH1A1POLB | |
| SCHEMBL30483246 | 0.84 | ATR (0.41) | CYP4F2CYP4A11LMNAALDH1A1POLB | |
| SCHEMBL28588995 | 0.84 | ATR (0.41) | CYP4F2CYP4A11LMNAALDH1A1POLB | |
| SCHEMBL21196054 | 0.84 | CYP4F2 (0.46) | CYP4F2CYP4A11LMNAALDH1A1POLB | |
| SCHEMBL21196196 | 0.82 | CYP4F2 (0.45) | CYP4F2CYP4A11LMNAALDH1A1POLB | |
| SCHEMBL20699355 | 0.82 | CYP4F2 (0.45) | CYP4F2CYP4A11LMNAALDH1A1POLB | |
| SCHEMBL30950246 | 0.82 | CYP4F2 (0.45) | CYP4F2CYP4A11LMNAALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116964046-B | PLK4 inhibitors and uses thereof | 上海齐鲁制药研究中心有限公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-116964046-A | PLK4 inhibitors and uses thereof | 上海齐鲁制药研究中心有限公司 | 2023-10-27 | — | — | CN | disclosed |
| CN-113004252-B | Aryl imidazole derivative and application thereof | 江苏先声药业有限公司 | 2023-06-09 | — | — | CN | disclosed |
| WO-2022184049-A1 | PLK4 INHIBITOR AND USE THEREOF | 上海齐鲁制药研究中心有限公司 | 2022-09-09 | — | — | WO | disclosed |
| CN-113004252-A | Aryl imidazole derivative and application thereof | 江苏先声药业有限公司 | 2021-06-22 | — | — | CN | disclosed |