SCHEMBL28575650

SCHEMBL28575650

CC(C)(C)OC(=O)NC(Cn1nccn1)[C@H]1COC(C)(C)O1

nearest known ligand 0.37

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
HCRTR2 O43614 2/20 0.37
HCRTR1 O43613 1/20 0.31
KDM4D Q6B0I6 1/20 0.31
CA1 P00915 1/20 0.30
CA2 P00918 1/20 0.30
CA7 P43166 1/20 0.30
RORC P51449 1/20 0.30
CTSK P43235 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20263097 0.85 HCRTR2 (0.35) HCRTR2HCRTR1RORC
SCHEMBL20263095 0.85 HCRTR2 (0.35) HCRTR2HCRTR1RORC
SCHEMBL28588817 0.81 HCRTR2 (0.40) HCRTR2CA1CA2CA7CTSK
SCHEMBL13725768 0.81 HCRTR2 (0.40) HCRTR2CA1CA2CA7CTSK
SCHEMBL28580334 0.80 HCRTR2 (0.39) HCRTR2CA1CA2CA7CTSK
SCHEMBL28580336 0.80 HCRTR2 (0.39) HCRTR2CA1CA2CA7CTSK
SCHEMBL29573275 0.80 ATM (0.42) CTSK
SCHEMBL28599433 0.80 SCN9A (0.36) HCRTR2HCRTR1
SCHEMBL28599432 0.80 SCN9A (0.36) HCRTR2HCRTR1
SCHEMBL13528024 0.75 HCRTR2 (0.40) HCRTR2HCRTR1CA1CA2CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107709301-B Pyrazole derivative or pharmacologically acceptable salt thereof 橘生药品工业株式会社 2021-06-22 CN disclosed