Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17B | O94768 | 1/20 | 0.43 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 3/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26192157 | 0.78 | JAK1 (0.36) | STK17BSTK17AMAPKAPK2TRPA1JAK1 | |
| SCHEMBL16879925 | 0.76 | METAP1 (0.40) | MEN1NPC1GAARAB9AKMT2A | |
| SCHEMBL27472749 | 0.76 | MAPKAPK2 (0.44) | STK17BSTK17AMAPKAPK2JAK3BTK | |
| SCHEMBL30962529 | 0.76 | MAPKAPK2 (0.44) | STK17BSTK17AMAPKAPK2JAK3BTK | |
| SCHEMBL19533547 | 0.72 | ATM (0.49) | MAPKAPK2SYKJAK3BTK | |
| SCHEMBL4756322 | 0.70 | NPC1 (0.44) | JAK1MEN1NPC1GAARAB9A | |
| SCHEMBL28576688 | 0.69 | CCNA2 (0.33) | FGFR1FGFR4DYRK1A | |
| SCHEMBL28575806 | 0.68 | STK17B (0.39) | STK17BSTK17AMEN1GAAKMT2A | |
| SCHEMBL24682199 | 0.68 | PI4KA (0.39) | FGFR1FGFR4NPC1RAB9A | |
| SCHEMBL113150 | 0.67 | MAP4K4 (0.57) | SYKJAK3BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112888696-A | Exonucleotidase inhibitors and methods of use thereof | 卡利泰拉生物科技公司 | 2021-06-01 | — | — | CN | disclosed |