Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Zolpidem. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 4/20 | 0.97 |
| ▸ | GABRB1 known ✓ | P18505 | 1/20 | 0.97 |
| ▸ | GABRG2 known ✓ | P18507 | 1/20 | 0.97 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.97 |
| ▸ | ALB | P02768 | 2/20 | 0.97 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.97 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.97 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.97 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.97 |
| ▸ | LMNA | P02545 | 1/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.97 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.97 |
| ▸ | HPGD | P15428 | 1/20 | 0.97 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.97 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.97 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.97 |
| ▸ | HTR2B | P41595 | 1/20 | 0.97 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.97 |
| ▸ | TSPO | P30536 | 2/20 | 0.56 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zolpidem SCHEMBL80516 | 0.99 | GABRB2 (1.00) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL5606185 | 0.99 | GABRB2 (1.00) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL2064875 | 0.97 | GABRB2 (0.97) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL5766080 | 0.97 | GABRB2 (0.97) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL28035123 | 0.97 | GABRB2 (0.97) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL15169819 | 0.97 | GABRB2 (0.97) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL2065026 | 0.97 | GABRB2 (0.97) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL2064446 | 0.96 | GABRB2 (0.95) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL5629758 | 0.96 | GABRB2 (0.95) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL29033236 | 0.95 | GABRB2 (0.93) | GABRB2GABRA1ALBOPRK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117942309-A | Preparation method of Sha Kuba triclosartan sodium and dapagliflozin double-layer tablet | 南京一心和医药科技有限公司 | 2024-04-30 | — | — | CN | claimed |
| CN-112739307-A | Infusion system | 吴制药有限公司 | 2021-04-30 | — | — | CN | claimed |
| CN-118184537-A | Preparation method of high-purity Sha Kuba valsartan sodium | 浙江普洛家园药业有限公司 | 2024-06-14 | — | — | CN | disclosed |
| CN-118141776-A | Sakuba/valsartan sodium tablet composition and preparation method thereof | 迪沙药业集团有限公司 | 2024-06-07 | — | — | CN | disclosed |
| CN-117942309-A | Preparation method of Sha Kuba triclosartan sodium and dapagliflozin double-layer tablet | 南京一心和医药科技有限公司 | 2024-04-30 | — | — | CN | disclosed |
| CN-117164474-A | Sakuba/valsartan sodium process impurity and preparation method thereof | 九江市中医医院 | 2023-12-05 | — | — | CN | disclosed |