GABRB2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL15406	0.61	20/20
Fipronil (SCHEMBL15088)	0.59	20/20
SCHEMBL41972	0.59	20/20
Fipronil (SCHEMBL44222)	0.59	20/20
Ethiprole (SCHEMBL27048)	0.56	20/20
SCHEMBL26584	0.51	20/20
SCHEMBL25897	0.51	20/20
SCHEMBL33214	0.52	19/20
SCHEMBL9107	0.56	12/20
SCHEMBL8532	1.00	11/20
SCHEMBL9035	0.56	10/20
SCHEMBL8632	0.54	10/20
SCHEMBL8856	0.53	10/20
SCHEMBL8670	0.57	9/20
SCHEMBL9273	0.53	9/20
SCHEMBL8931	0.51	9/20
SCHEMBL8932	0.51	9/20
Flumazenil (SCHEMBL79030)	1.00	8/20
SCHEMBL9163	0.58	8/20
SCHEMBL8941	0.54	8/20

Clinical trials — most relevant to GABRB2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Computational Assessment of GABA Receptor Modulation in PTSD	PHASE4	RECRUITING
Evaluating the Safety of Acute Baclofen in Methadone-maintained Individuals With Opiate Dependence.	PHASE4	COMPLETED
Safety of Ramelteon in Elderly Subjects	PHASE4	COMPLETED
The Effect of Oral Baclofen and Botulinum Toxin Treatments in Hemiplegic Spasticity on the Nociceptive Flexor Reflex	PHASE4	COMPLETED
Clonazepam Effects on Brain Oscillations and Cognition in Schizophrenia	PHASE4	WITHDRAWN
Safety and Efficacy Study of Ramelteon in Subjects With Chronic Insomnia	PHASE3	COMPLETED
Safety and Efficacy of Ramelteon and Doxepin in Subjects With Chronic Insomnia	PHASE2	COMPLETED
Efficacy and Safety of Ramelteon Combined With Gabapentin in Treating Patients With Insomnia	PHASE2	COMPLETED
Diazepam Trial in GAD65 Associated Epilepsy	PHASE1/PHASE2	WITHDRAWN
Efficacy of Bumetanide to Improve Cognitive Functions in Down Syndrome	PHASE2	RECRUITING
Effects of Baclofen on Presynaptic Inhibition in Humans	PHASE2	WITHDRAWN
PET Imaging of Brain Peripheral Benzodiazepine Receptors	PHASE1	COMPLETED
PET Whole Body Imaging Using a Peripheral Benzodiazepine Receptor Ligand [C-11]PBR28	PHASE1	COMPLETED
MEG Study of Acute STX209 Effects in ASD	EARLY_PHASE1	COMPLETED
Imaging the Effects of Zolpidem and Alprazolam in Healthy Volunteers at 3T	EARLY_PHASE1	UNKNOWN
Synaptic Mechanisms of Continuous Theta Burst Stimulation in Depression	EARLY_PHASE1	RECRUITING
Association of Brain Derived Neurotrophic Factor (BDNF) rs6265 Gene Polymorphism With Susceptibility to Epilepsy	nan	UNKNOWN
GABA Biomarkers in Dravet Syndrome	nan	RECRUITING
The Efficacy of Tianeptine Versus Pregabalin on Acute and Chronic Post Mastectomy Pain After Breast Cancer Surgery.	nan	COMPLETED
Cenobamate Efficacy in Individuals With Autoimmune Epilepsy	nan	ENROLLING_BY_INVITATION
Potential Synergistic Effect of Combined Blood Flow Restriction Training and Betaine Supplementation on Skeletal Muscle	nan	COMPLETED
Brain Changes in Patients With Focal Hand Dystonia	nan	COMPLETED
Oral Pregabalin Premedication for Postoperative Pain Relief	nan	UNKNOWN
Butyrate Supplementation in Children With Autism Spectrum Disorder (ASD) and Functional Gastrointestinal Disorders	nan	RECRUITING
Pilot Study Evaluating Neuro-Imaging Correlates of Epigenetic Finding in Prediction of Chronic Postsurgical Pain	nan	UNKNOWN
Investigating the Role of Diazepam on Brain Function and Chemistry in Psychosis Risk	nan	COMPLETED
Protocol Assessment of Motor Cortex rTMS for Treating Neuropathic Pain	nan	RECRUITING
Functional Study of Inhibitory Neurotransmission in the Human Epileptic Brain.	nan	RECRUITING
L-arginine add-on Therapy in Patients With Schizophrenia	nan	COMPLETED
The Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) on Working Memory	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a GABRB2 binder may also engage these)

Protein	Name	Similarity
P63137	—	1.000	P63137 →
D1LYT2	—	1.000	D1LYT2 →
GABRB1	Gamma-aminobutyric acid receptor subunit beta-1	0.997	landscape →
P0C2W5	—	0.996	P0C2W5 →
P63079	—	0.993	P63079 →
GABRB3	Gamma-aminobutyric acid receptor subunit beta-3	0.992	landscape →
P19019	—	0.992	P19019 →
P15431	—	0.991	P15431 →
P50571	—	0.991	P50571 →
P08220	—	0.990	P08220 →
P63138	—	0.990	P63138 →
P63080	—	0.989	P63080 →
P24045	—	0.969	P24045 →
P18508	—	0.968	P18508 →
P21548	—	0.965	P21548 →
GABRG2	Gamma-aminobutyric acid receptor subunit gamm	0.964	landscape →
Q5REA1	—	0.964	Q5REA1 →
P22723	—	0.963	P22723 →
P22300	—	0.961	P22300 →
P19969	—	0.959	P19969 →
P27681	—	0.957	P27681 →
P28473	—	0.956	P28473 →
GABRA5	Gamma-aminobutyric acid receptor subunit alpha-5	0.955	landscape →
Q8BHJ7	—	0.955	Q8BHJ7 →
P23574	—	0.954	P23574 →
Q08E50	—	0.952	Q08E50 →
Q9R0Y8	—	0.952	Q9R0Y8 →
P62813	—	0.951	P62813 →
Q4R534	—	0.950	Q4R534 →
P62812	—	0.949	P62812 →