Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | MITF | O75030 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | CRHBP | P24387 | 2/20 | 0.55 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | KLK7 | P49862 | 1/20 | 0.52 |
| ▸ | CASP6 | P55212 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28577456 | 1.00 | LMNA (0.64) | LMNAMAPTSMN1; SMN2POLBKMT2A | |
| SCHEMBL21729893 | 0.87 | POLB (0.79) | LMNAMAPTSMN1; SMN2POLBKMT2A | |
| SCHEMBL10175697 | 0.87 | LMNA (0.73) | LMNAMAPTSMN1; SMN2POLBKMT2A | |
| SCHEMBL28582449 | 0.86 | POLB (0.61) | LMNAMAPTPOLBKMT2AMEN1 | |
| SCHEMBL28575820 | 0.86 | LMNA (0.69) | LMNAMAPTSMN1; SMN2POLBKMT2A | |
| SCHEMBL28573999 | 0.86 | POLB (0.61) | LMNAMAPTPOLBKMT2AMEN1 | |
| SCHEMBL28575819 | 0.86 | LMNA (0.69) | LMNAMAPTSMN1; SMN2POLBKMT2A | |
| SCHEMBL28574002 | 0.86 | POLB (0.61) | LMNAMAPTPOLBKMT2AMEN1 | |
| SCHEMBL2610070 | 0.84 | LMNA (0.66) | LMNAMAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL28581179 | 0.84 | MEN1 (0.81) | LMNAMAPTSMN1; SMN2POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112778154-B | Aryl alkyl ether compound and derivative thereof, preparation method, pharmaceutical composition and application | 中国药科大学 | 2022-05-13 | — | — | CN | disclosed |
| CN-112778154-A | Aryl alkyl ether compound and derivative thereof, preparation method, pharmaceutical composition and application | 中国药科大学 | 2021-05-11 | — | — | CN | disclosed |