Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 10/20 | 0.64 |
| ▸ | CECR2 | Q9BXF3 | 6/20 | 0.62 |
| ▸ | BRD9 | Q9H8M2 | 4/20 | 0.61 |
| ▸ | TAF1 | P21675 | 3/20 | 0.58 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.53 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.53 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.53 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.53 |
| ▸ | EP300 | Q09472 | 1/20 | 0.53 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.53 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.53 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.53 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31589682 | 0.83 | BRD4 (0.70) | BRD4CECR2BRD9 | |
| SCHEMBL17748876 | 0.80 | BRD4 (0.74) | BRD4CECR2BRD9TAF1 | |
| SCHEMBL17748890 | 0.80 | CECR2 (0.75) | BRD4CECR2BRD9TAF1TRIM24 | |
| SCHEMBL17748893 | 0.79 | BRD9 (0.71) | BRD4CECR2BRD9TAF1TRIM24 | |
| SCHEMBL24866050 | 0.79 | BRD4 (0.76) | BRD4CECR2BRD9TAF1 | |
| SCHEMBL17748888 | 0.78 | BRD4 (1.00) | BRD4CECR2BRD9TAF1 | |
| SCHEMBL31590527 | 0.78 | BRD4 (0.74) | BRD4CECR2BRD9TAF1 | |
| SCHEMBL31589675 | 0.78 | BRD4 (0.74) | BRD4CECR2BRD9TAF1 | |
| SCHEMBL17748894 | 0.77 | BRD4 (1.00) | BRD4CECR2BRD9TAF1TRIM24 | |
| SCHEMBL17748906 | 0.77 | CECR2 (1.00) | BRD4CECR2BRD9TAF1TRIM24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107207493-B | Substituted pyrrolopyridines as bromodomain inhibitors | 基因泰克公司 | 2023-01-20 | — | — | CN | disclosed |
| CN-107108614-B | Substituted pyrrolopyridines as bromodomain inhibitors | 基因泰克公司 | 2021-06-01 | — | — | CN | disclosed |