SCHEMBL28579304

SCHEMBL28579304

CCS(=O)(=O)c1ccc(CNC(=O)c2ccc3c(c2)cc(Cc2ccc(OC(F)(F)F)cc2)n3C2CC2)cc1

nearest known ligand 0.69

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
RORC P51449 20/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18440842 0.90 RORC (0.74) RORC
SCHEMBL28603444 0.88 RORC (0.63) RORC
SCHEMBL19360554 0.88 RORC (0.69) RORC
SCHEMBL19360350 0.88 RORC (0.69) RORC
SCHEMBL19360602 0.87 RORC (0.62) RORC
SCHEMBL19360499 0.86 RORC (0.70) RORC
SCHEMBL19360571 0.86 RORC (0.74) RORC
SCHEMBL19360357 0.86 RORC (0.76) RORC
SCHEMBL28595332 0.85 RORC (0.80) RORC
SCHEMBL19360635 0.84 RORC (0.65) RORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107531679-B Aromatic amide derivative, preparation method and medical application thereof 江苏恒瑞医药股份有限公司 2021-07-02 CN disclosed