Bilobalide

Bilobalide

SCHEMBL285824

CC(C)(C)[C@]1(O)C[C@@H]2OC(=O)C[C@@]23C(=O)O[C@@H]2OC(=O)[C@H](O)[C@]213

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 1.00
MEN1 O00255 2/20 1.00
SMN1; SMN2 Q16637 2/20 1.00
THRB P10828 1/20 1.00
ALOX15 P16050 1/20 1.00
GLRA1 P23415 3/20 0.32
GLRA2 P23416 3/20 0.32
CYP2C9 P11712 1/20 0.32
HSD17B10 Q99714 1/20 0.32
GUSB P08236 1/20 0.32
PTAFR P25105 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bilobalide SCHEMBL19236272 1.00 KMT2A (1.00) KMT2AMEN1SMN1; SMN2THRBALOX15
Bilobalide SCHEMBL29410808 1.00 KMT2A (1.00) KMT2AMEN1SMN1; SMN2THRBALOX15
Bilobalide SCHEMBL14029382 1.00 KMT2A (1.00) KMT2AMEN1SMN1; SMN2THRBALOX15
Bilobalide SCHEMBL29410789 1.00 KMT2A (1.00) KMT2AMEN1SMN1; SMN2THRBALOX15
Bilobalide SCHEMBL16653675 1.00 KMT2A (1.00) KMT2AMEN1SMN1; SMN2THRBALOX15
Bilobalide SCHEMBL18327718 1.00 KMT2A (1.00) KMT2AMEN1SMN1; SMN2THRBALOX15
Bilobalide SCHEMBL13960090 1.00 KMT2A (1.00) KMT2AMEN1SMN1; SMN2THRBALOX15
Bilobalide SCHEMBL16452769 1.00 KMT2A (1.00) KMT2AMEN1SMN1; SMN2THRBALOX15
SCHEMBL29974351 0.84 MEN1 (0.72) KMT2AMEN1SMN1; SMN2THRBALOX15
SCHEMBL31364706 0.79 MEN1 (0.65) KMT2AMEN1SMN1; SMN2THRBALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 5266 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122005544-A Method for preparing VA-ECMO lung injury treatment drug by using ginkgolide A to regulate YARS1 中国人民解放军总医院第八医学中心 2026-05-12 CN claimed
US-12622941-B2 Anticoccidial composition comprising ginkgo leaves and use thereof CJ CHEILJEDANG CORPORATION (KR) 2026-05-12 US claimed
CN-122029157-A Bilobalide derivatives for the treatment of neurological diseases and cancers 香港中文大学 2026-05-12 CN claimed
CN-122012537-A Gene GbCYP A6 for promoting synthesis of ginkgolide and application thereof 扬州大学 2026-05-12 CN claimed
EP-4405047-B1 CANNABINOID FORMULATION FOR ORAL ADMINISTRATION CB21 PHARMA S R O (CZ) 2026-04-01 EP claimed
EP-3782619-B1 USE OF GINKGO BILOBA TERPENE LACTONE IN PREPARATION OF DRUGS FOR PREVENTION AND/OR TREATMENT OF TREMORS AND HEALTHCARE PRODUCTS CHENGDU BAIYU PHARMACEUTICAL CO LTD (CN) 2026-02-25 EP claimed
EP-4698662-A2 REGULATABLE CONTROLLED EXPRESSION OF A TRANSGENE IN PRIMATES AskBio Inc. (US) 2026-02-25 EP claimed
US-12545694-B2 Cannabidiol derivatives, preparation method thereof and use thereof CHENGDU BAIYU PHARMACEUTICAL CO., LTD. (CN) 2026-02-10 US claimed
US-20250339399-A1 SUPRAMOLECULAR SELF-ASSEMBLY SYSTEM BEIJING CREATRON INSTITUTE OF PHARMACEUTICAL RES CO LTD (CN) 2025-11-06 US claimed
US-12390503-B2 Ginkgo biloba leave extract capsule and preparation method therefor SPH XING LING SCI. & TECH. PHARMACEUTICAL CO., LTD. (CN) 2025-08-19 US claimed
US-5264216-A Treatment of bacterial infections INDENA SPA (IT) 1993-11-23 US claimed
EP-0556051-A1 Use of bilobalide and derivatives thereof for treating an infection in an individual and pharmaceutical compositions adapted for such use INDENA S.p.A. (IT) 1993-08-18 EP claimed
EP-0360556-B1 NEW EXTRACTS OF GINKGO BILOBA AND THEIR METHODS OF PREPARATION INDENA S.p.A. (IT) 1993-04-21 EP claimed
US-5202313-A Complexes with phospholipids; antiinflammatory agents INDENA S.P.A. (IT) 1993-04-13 US claimed
EP-0477968-A1 Extract from Ginkgo biloba leaves, in particular for intravenous injection or infusion, a method of preparation of the extract and ampoule preparations containing the extract Dr. Willmar Schwabe GmbH & Co. (DE) 1992-04-01 EP claimed
EP-0441279-A1 Bilobalide phospholipide complexes, their applications and formulations containing them INDENA S.p.A. (IT) 1991-08-14 EP claimed
EP-0436129-A1 Active component concentrates and new active component combinations from Ginkgo biloba leaves, their method of preparation and pharmaceuticals containing the active component concentrates or the active component combinations WALLINGSTOWN COMPANY LIMITED (IE) 1991-07-10 EP claimed
EP-0431535-A1 Extract from Ginkgo biloba leaves, its method of preparation and pharmaceuticals containing the extract Dr. Willmar Schwabe GmbH & Co. (DE) 1991-06-12 EP claimed
EP-0431536-A1 A method of preparation of an extract from Gingko biloba leaves. Dr. Willmar Schwabe GmbH & Co. (DE) 1991-06-12 EP claimed
US-4892883-A Pharmaceutical compositions containing bilobalide for the treatment of neuropathies Ai WILLMAN - SCHWABE GMBH & CO. (DE) 1990-01-09 US claimed