Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 15/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | PTGFR | P43088 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.37 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2859344 | 0.92 | MAPT (0.43) | MAPTCSNK2A1SMN1; SMN2 | |
| SCHEMBL2870379 | 0.83 | LYN (0.34) | — | |
| SCHEMBL2868877 | 0.76 | MAPT (0.43) | MAPTCSNK2A1SMN1; SMN2AKR1C3PTGFR | |
| SCHEMBL2863267 | 0.75 | JAK2 (0.37) | CSNK2A1 | |
| SCHEMBL2872707 | 0.75 | JAK2 (0.56) | MAPTCSNK2A1SMN1; SMN2AKR1C3 | |
| SCHEMBL24011039 | 0.71 | RET (0.54) | AKR1C3PTGFR | |
| SCHEMBL2862718 | 0.69 | JAK2 (0.55) | MAPT | |
| SCHEMBL3502465 | 0.67 | JAK2 (0.53) | MAPTSMN1; SMN2 | |
| SCHEMBL27915328 | 0.67 | KDM4E (0.52) | MAPTCSNK2A1SMN1; SMN2AKR1C3 | |
| SCHEMBL2929642 | 0.66 | TDP1 (0.53) | MAPTSMN1; SMN2AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200612-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009035575-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2009-03-19 | — | — | WO | disclosed |