Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 8/20 | 0.40 |
| ▸ | PTGFR | P43088 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2858246 | 0.76 | MAPT (0.43) | MAPTSMN1; SMN2AKR1C3CSNK2A1PTGFR | |
| SCHEMBL2872707 | 0.74 | JAK2 (0.56) | MAPTSMN1; SMN2AKR1C3CSNK2A1 | |
| SCHEMBL24011039 | 0.71 | RET (0.54) | AKR1C3PTGFRMAPK14 | |
| SCHEMBL2862718 | 0.68 | JAK2 (0.55) | MAPTMAPK3 | |
| SCHEMBL2859344 | 0.68 | MAPT (0.43) | MAPTSMN1; SMN2CSNK2A1KDM4ETDP1 | |
| SCHEMBL3502465 | 0.67 | JAK2 (0.53) | MAPTSMN1; SMN2KDM4E | |
| SCHEMBL27915328 | 0.66 | KDM4E (0.52) | MAPTSMN1; SMN2AKR1C3CSNK2A1KDM4E | |
| SCHEMBL2929642 | 0.66 | TDP1 (0.53) | MAPTSMN1; SMN2AKR1C3KDM4ETDP1 | |
| SCHEMBL3502703 | 0.65 | CSNK2A1 (0.42) | MAPTSMN1; SMN2CSNK2A1KDM4ETDP1 | |
| SCHEMBL22169872 | 0.63 | CAMKK2 (0.64) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200612-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-06-30 | — | — | EP | claimed |
| WO-2009035575-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2009-03-19 | — | — | WO | claimed |