SCHEMBL28582802

SCHEMBL28582802

COc1ccc2c(=O)[nH]c(C(C)(C)C)cc2c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.47
HSD17B10 Q99714 2/20 0.47
LMNA P02545 1/20 0.47
PARP15 Q460N3 1/20 0.44
PARP14 Q460N5 1/20 0.44
PARP10 Q53GL7 1/20 0.44
TNKS2 Q9H2K2 1/20 0.44
PARP2 Q9UGN5 1/20 0.44
TUBB4A P04350 2/20 0.44
TUBB P07437 2/20 0.44
TUBA3C P0DPH7 2/20 0.44
TUBA1B P68363 2/20 0.44
TUBA4A P68366 2/20 0.44
TUBB4B P68371 2/20 0.44
TUBB3 Q13509 2/20 0.44
TUBB2A Q13885 2/20 0.44
TUBB8 Q3ZCM7 2/20 0.44
TUBA3E Q6PEY2 2/20 0.44
TUBA1A Q71U36 2/20 0.44
TUBA1C Q9BQE3 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL741856 0.82 AXL (0.59) KDM4EHSD17B10LMNAPARP15PARP14
SCHEMBL26018335 0.78 KDM4E (0.49) KDM4EHSD17B10LMNAPARP15PARP14
SCHEMBL12302517 0.78 TDP2 (0.49) KDM4ELMNATUBB4ATUBBTUBA3C
SCHEMBL13729788 0.77 PARP1 (0.48) KDM4EHSD17B10LMNATNKS2ALDH1A1
SCHEMBL4316072 0.77 AXL (0.66) KDM4EHSD17B10LMNAAXLALDH1A1
SCHEMBL4773470 0.75 PARP1 (0.58) KDM4ELMNAALDH1A1HPGDGAA
SCHEMBL16591247 0.75 KDM4E (0.65) KDM4ELMNATNKS2ALDH1A1HPGD
SCHEMBL21524688 0.74 PDE3B (0.54) KDM4EHSD17B10LMNAALDH1A1HPGD
SCHEMBL4014895 0.73 MEN1 (0.53) KDM4EHSD17B10AXLALDH1A1HPGD
SCHEMBL28578511 0.73 AOC3 (0.49)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112876419-A Allylamine derivatives, process for producing the same and use thereof 四川科伦博泰生物医药股份有限公司 2021-06-01 CN disclosed