SCHEMBL28583286

SCHEMBL28583286

Nc1ccc(-c2ccc(NC3CCc4ccccc4C3)cc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.48
CA2 P00918 1/20 0.48
MTNR1A P48039 4/20 0.44
MTNR1B P49286 4/20 0.44
GRIN2B Q13224 4/20 0.44
GBA1 P04062 1/20 0.44
MAOA P21397 1/20 0.43
MAOB P27338 1/20 0.43
PLAU P00749 1/20 0.42
HDAC8 Q9BY41 2/20 0.40
SIGMAR1 Q99720 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4043115 0.82 GRIN2B (0.57) CA1CA2MTNR1AMTNR1BGRIN2B
Hydrochloric Acid SCHEMBL4053518 0.80 GRIN2B (0.56) CA1CA2MTNR1AMTNR1BGRIN2B
SCHEMBL10399460 0.80 MTNR1A (0.51) CA1CA2MTNR1AMTNR1BGRIN2B
SCHEMBL29033596 0.79 GRIN2B (0.54) CA1CA2MTNR1AMTNR1BGRIN2B
SCHEMBL30479468 0.79 GRIN2B (0.54) CA1CA2MTNR1AMTNR1BGRIN2B
SCHEMBL24427605 0.74 GRM5 (0.46) CA1CA2MTNR1AMTNR1BGRIN2B
SCHEMBL13573565 0.73 GRIN2B (0.77) CA1CA2GRIN2BMAOAMAOB
SCHEMBL10399768 0.71 TAOK1 (0.55) GRIN2BSIGMAR1
SCHEMBL28127425 0.70 POLB (0.47)
SCHEMBL2980045 0.68 GRIN2B (0.47) CA1CA2GRIN2BGBA1SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107698622-B Organic electronic device comprising a layer containing at least one metal-organic compound and at least one metal oxide UDC 爱尔兰有限责任公司 2021-06-29 CN disclosed