Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 3/20 | 0.55 |
| ▸ | CTSK | P43235 | 3/20 | 0.55 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.48 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 4/20 | 0.45 |
| ▸ | CTSB | P07858 | 2/20 | 0.45 |
| ▸ | REN | P00797 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30386785 | 1.00 | CTSS (0.55) | CTSSCTSKSCN9AKLK5CTSL | |
| SCHEMBL10436055 | 1.00 | CTSS (0.55) | CTSSCTSKSCN9AKLK5CTSL | |
| SCHEMBL28571315 | 0.93 | CTSS (0.57) | CTSSCTSKSCN9ACTSLCTSB | |
| SCHEMBL28571321 | 0.93 | CTSS (0.57) | CTSSCTSKSCN9ACTSLCTSB | |
| SCHEMBL30882337 | 0.93 | CTSS (0.57) | CTSSCTSKSCN9ACTSLCTSB | |
| SCHEMBL27335662 | 0.92 | CTSS (0.54) | CTSSCTSKSCN9AKLK5CTSL | |
| SCHEMBL9551282 | 0.92 | CTSS (0.54) | CTSSCTSKSCN9AKLK5CTSL | |
| SCHEMBL7351751 | 0.92 | CTSS (0.54) | CTSSCTSKSCN9AKLK5CTSL | |
| SCHEMBL9876266 | 0.92 | CTSS (0.54) | CTSSCTSKSCN9AKLK5CTSL | |
| SCHEMBL7276364 | 0.85 | KLK5 (0.44) | CTSSCTSKKLK5CTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117964684-A | MASP-2 inhibitors and methods of use | 奥默罗斯公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-117964683-A | MASP-2 inhibitors and methods of use | 奥默罗斯公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-112867706-A | MASP-2 inhibitors and methods of use | 奥默罗斯公司 | 2021-05-28 | — | — | CN | disclosed |