Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 4/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.44 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27525364 | 0.98 | GABRA1 (0.46) | GABRA1GABRB2NLRP3MAOAELANE | |
| SCHEMBL599099 | 0.80 | GABRA1 (0.57) | GABRA1GABRB2NLRP3ELANEPDK2 | |
| Bromide SCHEMBL2965541 | 0.78 | GABRA1 (0.44) | GABRA1GABRB2MGLLTP53ALDH1A1 | |
| Water SCHEMBL28182555 | 0.78 | GABRA1 (0.55) | GABRA1GABRB2NLRP3ELANEPDK2 | |
| Ammonia Solution, Strong SCHEMBL9357829 | 0.78 | GABRA1 (0.55) | GABRA1GABRB2NLRP3ELANEPDK2 | |
| SCHEMBL939264 | 0.75 | — | — | |
| SCHEMBL231467 | 0.74 | GABRA1 (0.46) | GABRA1GABRB2MAOAPDK2MGLL | |
| SCHEMBL22855413 | 0.74 | GABRA1 (0.46) | GABRA1GABRB2ELANEPDK2MGLL | |
| SCHEMBL9839875 | 0.73 | GABRA1 (0.50) | GABRA1GABRB2NLRP3ELANEPDK2 | |
| Iodide SCHEMBL18670641 | 0.73 | GABRA1 (0.44) | GABRA1GABRB2MGLLTP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110023425-B | Thermosetting powder coating compositions comprising dilauroyl peroxide | 帝斯曼知识产权资产管理有限公司 | 2021-09-24 | — | — | CN | disclosed |
| CN-109983089-B | Thermosetting powder coating compositions comprising peroxydicarbonates | 帝斯曼知识产权资产管理有限公司 | 2021-07-23 | — | — | CN | disclosed |