SCHEMBL28586403

SCHEMBL28586403

O=C=Nc1ccccc1Cc1cccc(Cc2ccccc2N=C=O)c1

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.46
GABRA1 P14867 1/20 0.43
GABRB2 P47870 1/20 0.43
TSHR P16473 1/20 0.37
BCL2 P10415 1/20 0.33
BCL2L1 Q07817 1/20 0.33
TRPA1 O75762 1/20 0.33
SIGMAR1 Q99720 2/20 0.33
PTPN1 P18031 1/20 0.33
DAO P14920 1/20 0.33
SLC6A2 P23975 1/20 0.32
SLC6A4 P31645 1/20 0.32
SLC6A3 Q01959 1/20 0.32
CYP1A2 P05177 1/20 0.32
ALDH1A1 P00352 1/20 0.32
HPGD P15428 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
HTR2A P28223 1/20 0.32
FEN1 P39748 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7757579 0.90 CYP3A4 (0.41) CYP3A4GABRA1GABRB2TSHRBCL2
SCHEMBL510928 0.89 CYP3A4 (0.44) CYP3A4GABRA1GABRB2TSHRBCL2
SCHEMBL28037071 0.89 CYP3A4 (0.47) CYP3A4GABRA1GABRB2TSHRTRPA1
SCHEMBL28576503 0.87 CYP3A4 (0.50) CYP3A4GABRA1GABRB2TSHRBCL2
SCHEMBL2906319 0.85 CYP3A4 (0.40) CYP3A4GABRA1GABRB2TSHRTRPA1
SCHEMBL18701450 0.85 CYP3A4 (0.50) CYP3A4GABRA1GABRB2TSHRTRPA1
SCHEMBL29404189 0.85 CYP3A4 (0.50) CYP3A4GABRA1GABRB2TSHRTRPA1
SCHEMBL15544 0.85 CYP3A4 (0.50) CYP3A4GABRA1GABRB2TSHRTRPA1
Methane SCHEMBL17504404 0.83 CYP3A4 (0.39) CYP3A4GABRA1GABRB2TSHRBCL2
SCHEMBL11211323 0.83 CYP3A4 (0.43) CYP3A4GABRA1GABRB2TSHRTRPA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108137779-B Biuret polyisocyanate compositions 温科莱斯法国公司 2021-04-20 CN disclosed