Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 12/20 | 1.00 |
| ▸ | CNR2 | P34972 | 2/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.61 |
| ▸ | PDE4A | P27815 | 1/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28591269 | 1.00 | SMPD1 (1.00) | SMPD1CNR2HDAC1HDAC8HDAC6 | |
| SCHEMBL9307263 | 0.86 | SMPD1 (0.76) | SMPD1CNR2PDE4B | |
| SCHEMBL28051119 | 0.86 | SMPD1 (0.75) | SMPD1PDE4B | |
| SCHEMBL9305512 | 0.86 | SMPD1 (0.75) | SMPD1PDE4B | |
| SCHEMBL28604170 | 0.86 | SMPD1 (0.75) | SMPD1PDE4B | |
| SCHEMBL28957152 | 0.85 | SMPD1 (0.73) | SMPD1CNR2PDE4B | |
| SCHEMBL4496535 | 0.84 | SMPD1 (0.72) | SMPD1PDE4B | |
| SCHEMBL11237246 | 0.84 | SMPD1 (0.72) | SMPD1CNR2 | |
| SCHEMBL9308281 | 0.83 | SMPD1 (0.71) | SMPD1CNR2PDE4APDE4BPDE4C | |
| SCHEMBL3373445 | 0.83 | SMPD1 (0.71) | SMPD1CNR2PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108250105-B | Acid sphingomyelinase inhibitor and application thereof in related diseases | 中国药科大学 | 2021-07-16 | — | — | CN | disclosed |