Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.42 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.42 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.42 |
| ▸ | PRKCA | P17252 | 2/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.30 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31440273 | 1.00 | JAK2 (0.42) | JAK2ROCK2PRKCQPRKCDROCK1 | |
| SCHEMBL16454353 | 0.79 | JAK2 (0.43) | JAK2ROCK2PRKCQPRKCDROCK1 | |
| SCHEMBL2018538 | 0.78 | SYK (0.38) | GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL17816271 | 0.78 | JAK2 (0.42) | JAK2ROCK2PRKCQPRKCDROCK1 | |
| SCHEMBL31543495 | 0.76 | GABRA1 (0.39) | GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL1661164 | 0.76 | GABRA1 (0.39) | GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL30632766 | 0.75 | GABRA1 (0.38) | GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL20015961 | 0.75 | GABRA1 (0.32) | GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL26686630 | 0.75 | GABRA1 (0.38) | GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL2020306 | 0.75 | CYP19A1 (0.37) | GABRA1GABRG2GABRB3GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112812105-A | Aminopyridyloxypyrazole derivative and preparation method and application thereof | 苏州阿尔脉生物科技有限公司 | 2021-05-18 | — | — | CN | disclosed |