Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.79 |
| ▸ | AXL | P30530 | 7/20 | 0.64 |
| ▸ | CAMKK2 | Q96RR4 | 6/20 | 0.64 |
| ▸ | SGK1 | O00141 | 3/20 | 0.64 |
| ▸ | CDC7 | O00311 | 1/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.51 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | PAK4 | O96013 | 1/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
| ▸ | INSR | P06213 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28591930 | 0.88 | MAP4K1 (1.00) | MAP4K1AXLCAMKK2SGK1ABL1 | |
| SCHEMBL28597600 | 0.84 | MAP4K1 (0.93) | MAP4K1AXLCAMKK2SGK1ABL1 | |
| SCHEMBL3768633 | 0.82 | AXL (0.92) | AXLCAMKK2SGK1CDC7PLK4 | |
| SCHEMBL28587404 | 0.82 | AXL (0.62) | MAP4K1AXLCAMKK2SGK1MAP3K11 | |
| SCHEMBL3765725 | 0.80 | MAP4K1 (0.63) | MAP4K1AXLSGK1NTRK1DYRK1A | |
| SCHEMBL3774587 | 0.79 | AXL (1.00) | AXLCAMKK2SGK1CDC7PLK4 | |
| SCHEMBL28591933 | 0.78 | MAP4K1 (0.63) | MAP4K1AXLCAMKK2SGK1CDC7 | |
| SCHEMBL3763777 | 0.78 | AXL (0.76) | AXLCAMKK2SGK1CDC7PLK4 | |
| SCHEMBL3761935 | 0.78 | CLK1 (0.65) | MAP4K1NTRK1DYRK1A | |
| SCHEMBL3767866 | 0.78 | PIK3CA (0.65) | MAP4K1SGK1NTRK1NEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113166139-A | Pyrrolo [2,3-b ] pyridines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-07-23 | — | — | CN | disclosed |