Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 4/20 | 0.62 |
| ▸ | CAMKK2 | Q96RR4 | 4/20 | 0.62 |
| ▸ | SGK1 | O00141 | 3/20 | 0.62 |
| ▸ | PAK1 | Q13153 | 3/20 | 0.61 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.58 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.57 |
| ▸ | MAP3K11 | Q16584 | 4/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.54 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.51 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28597666 | 0.90 | MAP4K1 (0.73) | AXLCAMKK2SGK1PAK1MAP4K1 | |
| SCHEMBL28587620 | 0.88 | PIK3CG (0.59) | AXLCAMKK2SGK1PAK1MAP4K1 | |
| SCHEMBL28605050 | 0.87 | MAP4K1 (0.71) | AXLCAMKK2SGK1PAK1MAP4K1 | |
| SCHEMBL28604463 | 0.86 | MAP3K11 (0.57) | AXLCAMKK2SGK1PAK1MAP4K1 | |
| SCHEMBL28597683 | 0.85 | MAP4K1 (0.59) | AXLCAMKK2SGK1PAK1MAP4K1 | |
| SCHEMBL31344461 | 0.84 | PAK1 (0.56) | CAMKK2PAK1MAP4K1PKN1MAP3K11 | |
| SCHEMBL31553233 | 0.83 | MAP4K1 (0.61) | SGK1PAK1MAP4K1PKN1MAP3K11 | |
| SCHEMBL29767435 | 0.83 | PAK1 (0.54) | CAMKK2PAK1MAP4K1PKN1MAP3K11 | |
| SCHEMBL28829877 | 0.83 | PAK1 (0.54) | CAMKK2PAK1MAP4K1PKN1MAP3K11 | |
| SCHEMBL28504766 | 0.82 | AXL (0.67) | AXLCAMKK2SGK1MAP4K1MAP3K11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113166139-A | Pyrrolo [2,3-b ] pyridines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-07-23 | — | — | CN | disclosed |