SCHEMBL28587715

SCHEMBL28587715

CS(=O)(=O)NCc1ccc(C(=O)NN)cc1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.70
KDM4E B2RXH2 2/20 0.68
POLB P06746 1/20 0.68
TSHR P16473 1/20 0.68
RECQL P46063 1/20 0.68
NAMPT P43490 1/20 0.57
NPC1 O15118 1/20 0.56
RAB9A P51151 1/20 0.56
SMN1; SMN2 Q16637 1/20 0.56
CA1 P00915 3/20 0.51
CA2 P00918 3/20 0.51
CA9 Q16790 1/20 0.51
MAPT P10636 4/20 0.49
GFER P55789 2/20 0.48
MPO P05164 1/20 0.48
CYP3A4 P08684 1/20 0.48
KDM5A P29375 1/20 0.48
BLM P54132 1/20 0.48
PMP22 Q01453 1/20 0.48
HIF1A Q16665 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3790611 0.84 KMT2A (0.72) KMT2AKDM4EPOLBTSHRRECQL
SCHEMBL2841195 0.82 KMT2A (1.00) KMT2AKDM4EPOLBTSHRRECQL
SCHEMBL23659579 0.82 KMT2A (0.74) KMT2AKDM4EPOLBTSHRRECQL
Hydrochloric Acid SCHEMBL3526720 0.81 KMT2A (0.96) KMT2AKDM4EPOLBTSHRRECQL
SCHEMBL13869051 0.79 KMT2A (0.70) KMT2AKDM4EPOLBTSHRRECQL
SCHEMBL2837637 0.79 KMT2A (0.70) KMT2AKDM4EPOLBTSHRRECQL
SCHEMBL13719506 0.78 KMT2A (0.68) KMT2AKDM4EPOLBTSHRRECQL
SCHEMBL10561443 0.77 MPO (0.59) KMT2AKDM4ECA1CA2CA9
SCHEMBL20597767 0.77 KMT2A (0.61) KMT2AKDM4EPOLBTSHRRECQL
SCHEMBL8750065 0.77 KMT2A (0.56) KMT2AKDM4EPOLBTSHRRECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107922362-B 1,3, 4-oxadiazole sulfonamide derivative compounds as histone deacetylase 6 inhibitors and pharmaceutical compositions containing the same 株式会社钟根堂 2021-06-15 CN disclosed