Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20718803 | 0.80 | TDP1 (0.44) | POLBKDM4ECTDSP1TDP1L3MBTL1 | |
| SCHEMBL1420954 | 0.75 | TDP1 (0.49) | POLBKDM4ECTDSP1TDP1L3MBTL1 | |
| SCHEMBL28623939 | 0.74 | ALDH1A1 (0.47) | KDM4ETDP1MAPTALDH1A1HTT | |
| SCHEMBL7647974 | 0.71 | TDP1 (0.41) | POLBKDM4ECTDSP1TDP1L3MBTL1 | |
| SCHEMBL1421203 | 0.70 | TDP1 (0.57) | POLBKDM4ECTDSP1TDP1L3MBTL1 | |
| SCHEMBL28615624 | 0.69 | ALDH1A1 (0.56) | POLBKDM4ECTDSP1TDP1L3MBTL1 | |
| SCHEMBL25405073 | 0.69 | HPGD (0.40) | POLBKDM4ECTDSP1TDP1L3MBTL1 | |
| SCHEMBL28913028 | 0.69 | PTGDR2 (0.30) | PTGDR2 | |
| SCHEMBL28913197 | 0.68 | CHRNA1 (0.32) | — | |
| SCHEMBL22321528 | 0.67 | ABCB1 (0.42) | POLBMAPTPKMALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108884097-B | Pyrimidine derivatives, preparation method thereof and application thereof in medicine | 浙江海正药业股份有限公司 | 2021-05-28 | — | — | CN | disclosed |