Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SUCNR1 | Q9BXA5 | 2/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28288257 | 0.86 | SUCNR1 (0.49) | SUCNR1KMT2AMEN1RAB9AKDM4E | |
| SCHEMBL27606943 | 0.84 | MEN1 (0.47) | SUCNR1KMT2AMEN1RAB9AALDH1A1 | |
| SCHEMBL5309600 | 0.83 | KMT2A (0.50) | KMT2AMEN1HTTRAB9AALDH1A1 | |
| SCHEMBL5308817 | 0.82 | HTT (0.46) | SUCNR1KMT2AMEN1HTTRAB9A | |
| SCHEMBL10988703 | 0.81 | NPC1 (0.56) | SUCNR1KMT2AMEN1HTTCYP19A1 | |
| Bromide SCHEMBL28619260 | 0.81 | KMT2A (0.49) | KMT2AMEN1HTTRAB9AALDH1A1 | |
| SCHEMBL18806846 | 0.81 | ALDH1A1 (0.48) | SUCNR1KMT2AMEN1HTTRAB9A | |
| SCHEMBL19768558 | 0.81 | CCR1 (0.55) | NR4A2KMT2AMEN1HTTCYP19A1 | |
| SCHEMBL28670340 | 0.81 | ALDH1A1 (0.42) | SUCNR1KMT2AMEN1RAB9AALDH1A1 | |
| SCHEMBL30883938 | 0.81 | CCR1 (0.55) | NR4A2KMT2AMEN1HTTCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109053725-B | 2- (tetrahydroquinoline-6-yl) -tetrahydro-1, 8-naphthyridine compound and preparation method and application thereof | 五邑大学 | 2021-06-08 | — | — | CN | disclosed |
| CN-109053725-A | A kind of 2- (tetrahydroquinoline -6- base)-tetrahydro -1,8- naphthyridine type compound and the preparation method and application thereof | 五邑大学 | 2018-12-21 | — | — | CN | disclosed |