SCHEMBL2858848

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL2864643	0.88	SMN1; SMN2 (0.56)	ROCK2SMN1; SMN2ROCK1PRKACAPRKACG
	SCHEMBL2868742	0.87	TTK (0.57)	ROCK2SMN1; SMN2MMP13ROCK1AURKA
	SCHEMBL2862186	0.86	SMN1; SMN2 (0.56)	ROCK2SMN1; SMN2MMP13ROCK1PRKACA
	SCHEMBL2862635	0.84	DGAT2 (0.56)	ROCK2SMN1; SMN2MMP13ROCK1AURKA
	SCHEMBL2872610	0.84	DGAT2 (0.56)	ROCK2SMN1; SMN2MMP13ROCK1AURKA
	SCHEMBL2864882	0.82	TP53 (0.53)	ROCK2SMN1; SMN2MMP13ROCK1PRKACA
	SCHEMBL2864651	0.81	APEX1 (0.52)	ROCK2SMN1; SMN2ROCK1PRKACAPRKACG
	SCHEMBL13198231	0.80	MAPT (0.51)	ROCK2SMN1; SMN2MMP13ROCK1PRKACA
	SCHEMBL2863001	0.79	NTRK1 (0.56)	ROCK2ROCK1HPGD
	SCHEMBL31632976	0.79	MAP2K4 (0.72)	GSK3AGSK3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.