Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 3/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 12/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
| ▸ | PLAT | P00750 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.34 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL616049 | 1.00 | F11 (0.38) | F11KLKB1PRSS1PRSS2PRSS3 | |
| SCHEMBL616978 | 0.92 | AAK1 (0.34) | F11KLKB1PRSS1PRSS2PRSS3 | |
| SCHEMBL16974676 | 0.89 | F11 (0.42) | F11KLKB1PRSS1PRSS2PRSS3 | |
| SCHEMBL15915827 | 0.89 | F11 (0.38) | F11KLKB1PRSS1PRSS2PRSS3 | |
| SCHEMBL15915824 | 0.89 | F11 (0.38) | F11KLKB1PRSS1PRSS2PRSS3 | |
| SCHEMBL18690161 | 0.88 | AAK1 (0.36) | F11AAK1 | |
| SCHEMBL18690163 | 0.88 | AAK1 (0.36) | F11AAK1 | |
| SCHEMBL30193841 | 0.88 | AAK1 (0.36) | F11AAK1 | |
| SCHEMBL16983835 | 0.87 | AAK1 (0.35) | AAK1 | |
| SCHEMBL15594121 | 0.86 | AAK1 (0.34) | F11AAK1MAP4K4HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108250199-B | Dihydropyridone P1 as factor XIA inhibitor | 百时美施贵宝公司 | 2021-07-16 | — | — | CN | disclosed |