Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.71 |
| ▸ | MAPT | P10636 | 3/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.69 |
| ▸ | RAB9A | P51151 | 2/20 | 0.64 |
| ▸ | KDR | P35968 | 3/20 | 0.64 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.64 |
| ▸ | KIT | P10721 | 1/20 | 0.64 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.64 |
| ▸ | BRAF | P15056 | 1/20 | 0.64 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.64 |
| ▸ | FLT1 | P17948 | 1/20 | 0.64 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.64 |
| ▸ | TEK | Q02763 | 1/20 | 0.64 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.63 |
| ▸ | BTK | Q06187 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2851320 | 0.85 | BRAF (0.60) | GAAMAPTL3MBTL1MAPK1TDP1 | |
| SCHEMBL22225314 | 0.85 | PTGS1 (0.71) | GAAMAPTRAB9AKDRPDGFRB | |
| SCHEMBL2853263 | 0.84 | GAA (0.66) | GAAMAPTL3MBTL1MAPK1TDP1 | |
| SCHEMBL2855525 | 0.84 | LCK (0.60) | GAAMAPTL3MBTL1MAPK1TDP1 | |
| SCHEMBL2857312 | 0.82 | CDK8 (0.79) | GAAMAPTL3MBTL1MAPK1TDP1 | |
| SCHEMBL2851294 | 0.81 | KDR (0.56) | GAAMAPTL3MBTL1MAPK1TDP1 | |
| SCHEMBL6508815 | 0.81 | ALDH1A1 (0.65) | GAAMAPTL3MBTL1MAPK1TDP1 | |
| SCHEMBL2193786 | 0.81 | PTGS1 (0.67) | GAAMAPTRAB9AKDRPTGS1 | |
| SCHEMBL2855530 | 0.79 | GAA (0.51) | GAAMAPTL3MBTL1MAPK1TDP1 | |
| SCHEMBL12412290 | 0.79 | MEN1 (0.71) | MAPTL3MBTL1RAB9AKDRPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2184285-B1 | HETEROCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2015-11-04 | — | — | EP | disclosed |
| US-8344135-B2 | Heterocyclic compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-01-01 | — | — | US | disclosed |
| US-20100249119-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | US | disclosed |
| EP-2184285-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2010-05-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249119-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | BRAF, NRAS, RAF1 | GAA 3803/4885MAPT 4439/4885L3MBTL1 3082/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.