SCHEMBL2859415

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL4386344	0.92	EGFR (0.41)	EGFRDHODHCD274HDAC3HDAC4
	SCHEMBL4392152	0.90	EGFR (0.45)	EGFRCD274HDAC3HDAC4HDAC1
	SCHEMBL2857243	0.89	EGFR (0.39)	EGFRCD274HDAC3HDAC4HDAC1
	SCHEMBL4382698	0.85	EGFR (0.42)	EGFRDHODHHDAC3HDAC4HDAC1
	SCHEMBL4381418	0.84	EGFR (0.36)	EGFRCD274HDAC3HDAC4HDAC1
	SCHEMBL4393717	0.84	EGFR (0.41)	EGFRALDH1A1CAPN1
	SCHEMBL2866502	0.81	EGFR (0.43)	EGFRHDAC3HDAC4HDAC1HDAC7
	SCHEMBL4380021	0.80	CYP4F2 (0.52)	HDAC6CYP4F2CYP4A11
	SCHEMBL4384140	0.79	EGFR (0.46)	EGFRHDAC3HDAC4HDAC1HDAC7
	SCHEMBL4384233	0.77	ABCG2 (0.33)	EGFRHDAC3HDAC4HDAC1HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.