Sugi Predict

Sugi Predict / Targets / HEATR1

HEATR1

HEAT repeat-containing protein 1 · Q9H583 · HEATR1 on Sugi Atlas →

0 patent compounds predicted against HEATR1, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to HEATR1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Effects of Liraglutide on ER Stress in Obese Patients With Type 2 Diabetes PHASE4UNKNOWN
Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU) PHASE2/PHASE3ACTIVE_NOT_RECRUITING
Phase 1/ Phase 2 Study to Assess Safety and Efficacy of Orally Administered JBI-802 in Subjects With Myeloproliferative Neoplasms (MPN) and Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN) With Thrombocytosis PHASE1/PHASE2RECRUITING
A Phase 2 Study to Investigate the Clinical Activity of IPI-504 in Patients With Hormone-resistant Prostate Cancer PHASE2COMPLETED
Heat Therapy, Functional Capacity, and Vascular Health in Older Adults PHASE1/PHASE2COMPLETED
Targeting Endoplasmic Reticulum Stress in Human Hypertension PHASE1/PHASE2RECRUITING
Influence of Genetics in Pain Sensitivity PHASE2COMPLETED
LBH589 Plus Decitabine for Myelodysplastic Syndromes (MDS) or Acute Myeloid Leukemia (AML) PHASE1/PHASE2COMPLETED
Study of Oral CNF2024 (BIIB021) in Advanced Solid Tumors PHASE1COMPLETED
HS-201, an HSP90 Inhibitor-linked Verteporfin for Detection of Solid Malignancies PHASE1WITHDRAWN
Safety and Pharmacology of SNX-5422 Plus Carboplatin and Paclitaxel in Subjects With Solid Tumors PHASE1COMPLETED
Once or Twice Daily Administration of BIIB021 to Subjects With Advanced Solid Tumors PHASE1COMPLETED
Safety and Pharmacology Study of SNX-5422 in Subjects With Resistant Lung Adenocarcinoma PHASE1COMPLETED
Exercise on Expression of Heat Shock Protein 70 in Arterial Risk nanCOMPLETED
Perfusion-Induced Hyperthermia for Metastatic Carcinoma nanCOMPLETED
LncRNA Nicotinamide Nucleotide Transhydrogenase-Antisense RNA1 NNT-AS1 in CRC nanCOMPLETED
Role of Sorcin and Annexin A3 in Breast Cancer Patients nanUNKNOWN
Chronic Heat Therapy for Improving Vascular Health nanCOMPLETED
Acute Passive Heating in Healthy Older Adults nanCOMPLETED
Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq) nanRECRUITING
Steroid Treatment of Idiopathic Nephrotic Syndrome nanCOMPLETED
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Cardioprotective Benefit of Passive Heat Therapy in Higher-Level Spinal Cord Injury: Safety and Proof of Concept nanUNKNOWN
Establishment of Human Cellular Disease Models for Wilson Disease nanCOMPLETED
Possible Diagnostic Protein Markers in Schistosoma Related Bladder Diseases. nanNOT_YET_RECRUITING
Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia nanRECRUITING
Identification of Genes and Pathogenesis Involved in Familial Thoracic Aortic Aneurysm nanCOMPLETED
The Role of HSP90 in Peripheral Vascular Lesions of Diabetic Atherosclerosis nanCOMPLETED
Heat Therapy and Strength Training Effects in Individuals With Type 2 Diabetes nanUNKNOWN
Genetic Characterization of Parkinson's Disease nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a HEATR1 binder may also engage these)

ProteinNameSimilarity
Q9DEI1 — 0.997 Q9DEI1 →
Q6PQD5 — 0.996 Q6PQD5 →
E1C231 — 0.996 E1C231 →
Q6PR54 — 0.996 Q6PR54 →
SMG1 Serine/threonine-protein kinase SMG1 0.996 landscape →
Q8WN22 — 0.996 Q8WN22 →
P97313 — 0.996 P97313 →
E1C2Z0 — 0.996 E1C2Z0 →
E1BGH8 — 0.995 E1BGH8 →
B1AUR6 — 0.995 B1AUR6 →
Q8BKX6 — 0.994 Q8BKX6 →
F6S215 — 0.994 F6S215 →
Q5ZLS8 — 0.994 Q5ZLS8 →
E9PVA8 — 0.994 E9PVA8 →
RIF1 Telomere-associated protein RIF1 0.993 landscape →
Q7SY48 — 0.993 Q7SY48 →
GCN1 Stalled ribosome sensor GCN1 0.993 landscape →
O74447 — 0.993 O74447 →
Q6TNU3 — 0.992 Q6TNU3 →
Q6A009 — 0.992 Q6A009 →
Q96N23 — 0.992 Q96N23 →
Q8C3Y4 — 0.992 Q8C3Y4 →
Q8H0T4 — 0.992 Q8H0T4 →
Q8BJW5 — 0.992 Q8BJW5 →
Q3TQQ9 — 0.992 Q3TQQ9 →
Q3URQ0 — 0.992 Q3URQ0 →
Q62388 — 0.992 Q62388 →
Q14D04 — 0.992 Q14D04 →
Q6ZQK0 — 0.992 Q6ZQK0 →
Q5JWR5 — 0.992 Q5JWR5 →