Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PREP | P48147 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29126183 | 0.98 | HPGD (0.49) | HPGDSMN1; SMN2NPC1MAPTHTT | |
| SCHEMBL8418257 | 0.82 | SMN1; SMN2 (0.38) | HPGDSMN1; SMN2NPC1MAPTHTT | |
| SCHEMBL7858182 | 0.77 | HPGD (0.68) | HPGDSMN1; SMN2MAPTUSP2ALDH1A1 | |
| SCHEMBL5053 | 0.77 | HPGD (0.68) | HPGDSMN1; SMN2MAPTUSP2ALDH1A1 | |
| SCHEMBL29060341 | 0.76 | KMT2A (0.41) | HPGDSMN1; SMN2NPC1MAPTHTT | |
| SCHEMBL19852529 | 0.76 | HPGD (0.71) | HPGDSMN1; SMN2NPC1MAPTHTT | |
| SCHEMBL18097955 | 0.76 | HPGD (0.71) | HPGDSMN1; SMN2NPC1MAPTHTT | |
| SCHEMBL60470 | 0.76 | HPGD (0.71) | HPGDSMN1; SMN2NPC1MAPTHTT | |
| SCHEMBL2077166 | 0.76 | HPGD (0.71) | HPGDSMN1; SMN2NPC1MAPTHTT | |
| SCHEMBL21707988 | 0.76 | HPGD (0.71) | HPGDSMN1; SMN2NPC1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112204028-B | tetrahydro-1H-pyrazino [2,1-a ] isoindoloquinoline compounds for use in the treatment of autoimmune diseases | 豪夫迈·罗氏有限公司 | 2023-12-29 | — | — | CN | disclosed |
| CN-113105475-B | Inhibitors of bruton's tyrosine kinase and methods of use thereof | 詹森药业有限公司 | 2022-09-09 | — | — | CN | disclosed |
| CN-113105475-A | Inhibitors of bruton's tyrosine kinase and methods of use thereof | 詹森药业有限公司 | 2021-07-13 | — | — | CN | disclosed |