Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.45 |
| ▸ | STS | P08842 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8182758 | 1.00 | HPGD (0.51) | HPGDHRH3SMN1; SMN2RECQLEPHX1 | |
| SCHEMBL30885566 | 0.90 | HPGD (0.62) | HPGDHRH3SMN1; SMN2RECQLEPHX1 | |
| SCHEMBL1973022 | 0.87 | HPGD (0.59) | HPGDSMN1; SMN2RECQLEPHX1PTPN2 | |
| SCHEMBL1119307 | 0.87 | HPGD (0.59) | HPGDSMN1; SMN2RECQLEPHX1PTPN2 | |
| SCHEMBL1968331 | 0.87 | HPGD (0.59) | HPGDSMN1; SMN2RECQLEPHX1PTPN2 | |
| SCHEMBL9675197 | 0.84 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL4493181 | 0.83 | HRH3 (0.54) | HPGDHRH3SMN1; SMN2RECQLEPHX1 | |
| SCHEMBL4499465 | 0.83 | HRH3 (0.54) | HPGDHRH3SMN1; SMN2RECQLEPHX1 | |
| SCHEMBL750380 | 0.83 | HRH3 (0.54) | HPGDHRH3SMN1; SMN2RECQLEPHX1 | |
| SCHEMBL10774942 | 0.82 | HRH3 (0.52) | HPGDHRH3SMN1; SMN2RECQLEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108602823-B | Spiro-condensed pyrrolidine derivatives as Deubiquitinase (DUB) inhibitors | 特殊治疗有限公司 | 2022-04-01 | — | — | CN | disclosed |
| CN-108884068-B | 1-cyano-pyrrolidine derivatives as DUB inhibitors | 特殊治疗有限公司 | 2021-02-26 | — | — | CN | disclosed |