Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | STS | P08842 | 4/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL750380 | 1.00 | HRH3 (0.54) | HRH3HPGDRECQLHSD17B10MEN1 | |
| SCHEMBL4493181 | 1.00 | HRH3 (0.54) | HRH3HPGDRECQLHSD17B10MEN1 | |
| SCHEMBL27698678 | 0.90 | ALDH1A1 (0.50) | HRH3HPGDHSD17B10MEN1ALDH1A1 | |
| SCHEMBL1842901 | 0.90 | ALDH1A1 (0.50) | HRH3HPGDHSD17B10MEN1ALDH1A1 | |
| SCHEMBL310852 | 0.89 | HRH3 (0.60) | HRH3HPGDRECQLHSD17B10MEN1 | |
| SCHEMBL30885566 | 0.86 | HPGD (0.62) | HRH3HPGDRECQLHSD17B10MEN1 | |
| SCHEMBL410054 | 0.85 | HRH3 (0.44) | HRH3HPGDRECQLHSD17B10MEN1 | |
| SCHEMBL10774942 | 0.85 | HRH3 (0.52) | HRH3HPGDRECQLHSD17B10MEN1 | |
| SCHEMBL8182758 | 0.83 | HPGD (0.51) | HRH3HPGDRECQLHSD17B10MEN1 | |
| SCHEMBL28595178 | 0.83 | HPGD (0.51) | HRH3HPGDRECQLHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7598392-B2 | 2-amido-4-phenylthiazole derivatives, the preparation and the therapeutic use thereof | SANOFI-AVENTIS (FR) | 2009-10-06 | — | — | US | disclosed |
| US-20070259847-A1 | 2-Amido-4-phenylthiazole Derivatives, The Preparation And The Therapeutic Use Thereof | SANOFI-AVENTIS (FR) | 2007-11-08 | — | — | US | disclosed |
| CN-101065376-A | 2-Amido-4-phenylthiazole derivatives, their preparation and therapeutic use | SANOFI AVENTIS (FR) | 2007-10-31 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259847-A1 | 2-Amido-4-phenylthiazole Derivatives, The Preparation And The Therapeutic Use Thereof | PKD2, TPMT, PKD1 | HRH3 724/4885HPGD 888/4885RECQL 625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.